Investigating Serotonin Dynamics and Simulating Effects of Antidepressants Using Variation in Enzyme Expression

January 23, 2024
Undergraduate Research

By Alexander Diefes

Duke University

doi.org/10.55894/dv2.21

Synopsis

Depression is often treated with selective serotonin reuptake inhibitors (SSRIs), but some patients do not show improvements in their symptoms while taking them. Using a mathematical model of serotonin, we simulate the effects of various antidepressants and predict which factors may influence SSRI success.

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